Add to ORKGAims/hypothesis LARS2 has been previously identified as a potential type 2 diabetes susceptibility gene through the low-frequency H324Q (rs71645922) variant (minor allele frequency [MAF] 3.0%). However, this association did not achieve genome-wide levels of significance. The aim of this study was to establish the true contribution of this variant and common variants in LARS2 (MAF>5%) to type 2 diabetes risk. Methods We combined genome-wide association data (n= 10,128) from the DIAGRAM consortium with independent data derived from a tagging single nucleotide polymor-phism (SNP) approach in Dutch individuals (n=999) and took forward two SNPs of interest to replication in up to 11,163 Dutch participants (rs17637703 and rs952621). I
To access publisher's full text version of this article. Please click on the hyperlink in Additional...
To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we ...
The molecular mechanisms involved in the development of type 2 diabetes are poorly understood. Start...
LARS2 has been previously identified as a potential type 2 diabetes susceptibility gene through the ...
AIMS/HYPOTHESIS: LARS2 has been previously identified as a potential type 2 diabetes susceptibility ...
Aims/hypothesis Recent genome-wide association studies performed in selected patients and control pa...
textabstractMultiple genes, interacting with the environment, contribute to the susceptibility to ty...
The genetic architecture of common traits, including the number, frequency, and effect sizes of inhe...
Type 2 diabetes is rapidly increasing worldwide thereby posing a severe burden on individual and pub...
OBJECTIVE—In the present study, we aimed to validate the type 2 diabetes susceptibility alleles iden...
To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we ...
To characterise type 2 diabetes (T2D) associated variation across the allele frequency spectrum, we ...
Genome-wide association (GWA) studies have identified multiple loci at which common variants modestl...
To characterise type 2 diabetes (T2D) associated variation across the allele frequency spectrum, we ...
To access publisher's full text version of this article. Please click on the hyperlink in Additional...
To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we ...
The molecular mechanisms involved in the development of type 2 diabetes are poorly understood. Start...
LARS2 has been previously identified as a potential type 2 diabetes susceptibility gene through the ...
AIMS/HYPOTHESIS: LARS2 has been previously identified as a potential type 2 diabetes susceptibility ...
Aims/hypothesis Recent genome-wide association studies performed in selected patients and control pa...
textabstractMultiple genes, interacting with the environment, contribute to the susceptibility to ty...
The genetic architecture of common traits, including the number, frequency, and effect sizes of inhe...
Type 2 diabetes is rapidly increasing worldwide thereby posing a severe burden on individual and pub...
OBJECTIVE—In the present study, we aimed to validate the type 2 diabetes susceptibility alleles iden...
To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we ...
To characterise type 2 diabetes (T2D) associated variation across the allele frequency spectrum, we ...
Genome-wide association (GWA) studies have identified multiple loci at which common variants modestl...
To characterise type 2 diabetes (T2D) associated variation across the allele frequency spectrum, we ...
To access publisher's full text version of this article. Please click on the hyperlink in Additional...
To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we ...
The molecular mechanisms involved in the development of type 2 diabetes are poorly understood. Start...