Prediction and Prevention of Diabetes (PPP)-Botnia Study and

OBJECTIVE—Two independent genome-wide association stud-ies for type 2 diabetes in Japanese subjects have recently identified common variants in the KCNQ1 gene that are strongly associated with type 2 diabetes. Here we studied whether a common variant in KCNQ1 would influence BMI as well as insulin secretion and action and predict future type 2 diabetes in subjects from Sweden and Finland. RESEARCH DESIGN AND METHODS—Risk of type 2 diabe-tes conferred by KCNQ1 rs2237895 was studied in 2,830 type 2 diabetic case subjects and 3,550 control subjects from Sweden (Malmo ̈ Case-Control) and prospectively in 16,061 individuals from the Malmo ̈ Preventive Project (MPP). Association between genotype and insulin secretion/action was assessed cross-sectionally in 3,298 nondiabetic subjects from the Prevalence