Relationships between osteocalcin, glucose metabolism, and adiponectin in obese children: is there crosstalk between bone tissue and glucose metabolism

In tro duc ti on Adipose tissue, which acts as an endocrine tissue, plays an important role in the regulation of insulin sensitivity both in the adipocytes and in other tissues (1). Studies have emphasized the fact that adiponectin, which is secreted from the adipose tissue and is known to increase insulin sensitivity, is found in remarkably low concentrations in patients with metabolic syndrome. It has been shown that adiponectin in vivo improves insulin resistance in many tissues (2). In recent years, it has been reported that the skeletal system also plays a role in the regulation of energy and glucose metabolism (3). The presumed protective effect of obesity on osteoporosis has urged researchers to think about the presence of hormones that affect both the bones and the energy metabolism. The first rodent studies showed tha