Add to ORKGBackground: Caspase-mediated cleavage and proteasomal degradation of ubiquitinated proteins are two independent mechanisms for the regulation of protein stability and cellular function. We previously reported BAG3 overexpression protected ubiquitinated clients, such as AKT, from proteasomal degradation and conferred cytoprotection against heat shock. We hypothesized that the BAG3 protein is regulated by proteolysis. Methodology/Principal Findings: Staurosporine (STS) was used as a tool to test for caspase involvement in BAG3 degradation. MDA435 and HeLa human cancer cell lines exposed to STS underwent apoptosis with a concomitant time and dose-dependent loss of BAG3, suggesting the survival role of BAG3 was subject to STS regulation. zVAD-f...
Neoplasia pathogenesis and resistance to therapy are largely determined by acquired resistance to ap...
Co-chaperone proteins that share the Bcl-2-associated athanogene (BAG) domain are characterized by t...
Eukaryotic cells use autophagy and the ubiquitin–proteasome system as their major protein degradatio...
Caspase-mediated cleavage and proteasomal degradation of ubiquitinated proteins are two independent ...
Background: BAG3 was identified as a co-chaperone of the heat shock protein (Hsp) 70, which helps, t...
Background: BAG3 was identified as a co-chaperone of the heat shock protein (Hsp) 70, which helps, t...
Background: BAG3 was identified as a co-chaperone of the heat shock protein (Hsp) 70, which helps, t...
Background: BAG3 was identified as a co-chaperone of the heat shock protein (Hsp) 70, which helps, t...
Stress-induced apoptosis regulates neoplasia pathogenesis and response to therapy. Indeed, cell tran...
Stress-induced apoptosis regulates neoplasia pathogenesis and response to therapy. Indeed, cell tran...
Deregulation of apoptosis is responsible for diseases that involve defects in the death pathway, suc...
Deregulation of apoptosis is responsible for diseases that involve defects in the death pathway, suc...
Deregulation of apoptosis is responsible for diseases that involve defects in the death pathway, suc...
Deregulation of apoptosis is responsible for diseases that involve defects in the death pathway, suc...
Stress-induced apoptosis regulates neoplasia pathogenesis and response to therapy. Indeed, cell tran...
Neoplasia pathogenesis and resistance to therapy are largely determined by acquired resistance to ap...
Co-chaperone proteins that share the Bcl-2-associated athanogene (BAG) domain are characterized by t...
Eukaryotic cells use autophagy and the ubiquitin–proteasome system as their major protein degradatio...
Caspase-mediated cleavage and proteasomal degradation of ubiquitinated proteins are two independent ...
Background: BAG3 was identified as a co-chaperone of the heat shock protein (Hsp) 70, which helps, t...
Background: BAG3 was identified as a co-chaperone of the heat shock protein (Hsp) 70, which helps, t...
Background: BAG3 was identified as a co-chaperone of the heat shock protein (Hsp) 70, which helps, t...
Background: BAG3 was identified as a co-chaperone of the heat shock protein (Hsp) 70, which helps, t...
Stress-induced apoptosis regulates neoplasia pathogenesis and response to therapy. Indeed, cell tran...
Stress-induced apoptosis regulates neoplasia pathogenesis and response to therapy. Indeed, cell tran...
Deregulation of apoptosis is responsible for diseases that involve defects in the death pathway, suc...
Deregulation of apoptosis is responsible for diseases that involve defects in the death pathway, suc...
Deregulation of apoptosis is responsible for diseases that involve defects in the death pathway, suc...
Deregulation of apoptosis is responsible for diseases that involve defects in the death pathway, suc...
Stress-induced apoptosis regulates neoplasia pathogenesis and response to therapy. Indeed, cell tran...
Neoplasia pathogenesis and resistance to therapy are largely determined by acquired resistance to ap...
Co-chaperone proteins that share the Bcl-2-associated athanogene (BAG) domain are characterized by t...
Eukaryotic cells use autophagy and the ubiquitin–proteasome system as their major protein degradatio...