Research Article Electroencephalographic Changes Associated with Antinociceptive Actions of Lidocaine, Ketamine, Meloxicam, and Morphine Administration in Minimally Anaesthetized Dogs

Copyright © 2015 Ubedullah Kaka et al.This is an open access article distributed under theCreativeCommonsAttribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Effects of ketamine and lidocaine on electroencephalographic (EEG) changes were evaluated in minimally anaesthetized dogs, subjected to electric stimulus. Six dogs were subjected to six treatments in a crossover design with a washout period of one week. Dogs were subjected to intravenous boluses of lidocaine 2mg/kg, ketamine 3mg/kg, meloxicam 0.2mg/kg, morphine 0.2mg/kg and loading doses of lidocaine 2mg/kg followed by continuous rate infusion (CRI) of 50 and 100mcg/kg/min, and ketamine 3mg/kg followed by CRI of 10 and 50mcg/kg/min. Electroencephalogram was recorded during electrical stimulation prior to any drug treatment (before treatment) and during electrical stimulation following treatment with the drugs (after treatment) unde