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Purpose: Overactive bladder (OAB) is a clinical syndrome that is currently treated ini-tially with anticholinergics, although some other therapeutic alternatives exist, such as neuromodulation, botulinum toxin, and posterior tibial nerve stimulation (PTNS). The purpose of this study was to assess the efficacy of PTNS in patients with OAB re-fractory to anticholinergics. Materials and Methods: We present a cohort study of 14 women with OAB to whom we applied PTNS. We assessed (before and after the treatment) the diurnal micturi-tional frequency, the nocturnal micturitional frequency, urgency episodes, and urge incontinence episodes. Results were analyzed by using the Wilcoxon test for non-parametric samples. Results: We observed statistically significant improvement in the diurnal micturitional frequency (p=0.05), in episodes of micturitional urgency (p=0.03), and in episodes of urge incontinence (p=0.004). A total of 50 % of the patients felt subjective improvement from their pathology. Conclusions: PTNS is a valid, minimally invasive treatment option with minimum mor-bidity for patients with OAB refractory to treatment with anticholinergics. Key Words: Cholinergics antagonist; Tibial nerve; Urinary bladder overactive This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Licens