Add to ORKGCell-mediated transmission and dissemination of sexually-acquired human immunodeficiency virus 1 (HIV-1) in the host involves the migration of immature dendritic cells (iDCs). iDCs migrate in response to the HIV-1 envelope protein, gp120, and inhibiting such migration may limit the mucosal transmission of HIV-1. In this study, we elucidated the mechanism of HIV-1-gp120-induced transendothelial migration of iDCs. We found that gp120 enhanced the binding of Wiskott-Aldrich Syndrome protein (WASp) and the Actin-Related Protein 2/3 (Arp2/3) complex with b-actin, an interaction essential for the proper formation of podosomes, specialized adhesion structures required for the migration of iDCs through different tissues. We further identified Leuko...
DCs are critical to the early events of HIV-1 infection. They are the first cells that HIV-1 encount...
Dendritic cells (DCs) are essential antigen-presenting cells for the induction of immunity against p...
Macrophages are one of the three main human cell types infected by HIV-1. They are highly plastic ce...
Cell-mediated transmission and dissemination of sexually-acquired human immunodeficiency virus 1 (HI...
Dendritic cells are among the first cells to encounter sexually acquired human immunodeficiency viru...
Abstract Background Slit2 is a ~ 200 kDa secreted glycoprotein that has been recently shown to regul...
Targeting dendritic cell (DC) functions such as migration is a pivotal mechanism used by HIV-1 to di...
<p>(<b>A</b>) iMDDC transwell migration: cells were incubated with Slit2N, Slit2 negative control, o...
HIV-1 cell-to-cell transmission confers a strong advantage as it increases efficiency of transfer up...
<p>(<b>A</b>) HIV-1-gp120 induces podosome formation, and the migration of iMDDCs. (<b>B</b>) Slit2/...
<p>(<b>A</b>) Robo4 immunoprecipitation of α<sub>5</sub>β<sub>1</sub> integrin by Western blot analy...
A hallmark of many pathogenic diseases is localized inflammation and influx of leukocytes. The neuro...
HIV-1 traffics through dendritic cells (DCs) en route to establishing a productive infection in T ly...
Dendritic cells (DC) are one of the earliest targets of HIV-1 infection acting as a ‘Trojan Horse', ...
<p>(<b>A</b>) Representative Western blot analysis of phosphorylated c-Src in L-LECs after preincuba...
DCs are critical to the early events of HIV-1 infection. They are the first cells that HIV-1 encount...
Dendritic cells (DCs) are essential antigen-presenting cells for the induction of immunity against p...
Macrophages are one of the three main human cell types infected by HIV-1. They are highly plastic ce...
Cell-mediated transmission and dissemination of sexually-acquired human immunodeficiency virus 1 (HI...
Dendritic cells are among the first cells to encounter sexually acquired human immunodeficiency viru...
Abstract Background Slit2 is a ~ 200 kDa secreted glycoprotein that has been recently shown to regul...
Targeting dendritic cell (DC) functions such as migration is a pivotal mechanism used by HIV-1 to di...
<p>(<b>A</b>) iMDDC transwell migration: cells were incubated with Slit2N, Slit2 negative control, o...
HIV-1 cell-to-cell transmission confers a strong advantage as it increases efficiency of transfer up...
<p>(<b>A</b>) HIV-1-gp120 induces podosome formation, and the migration of iMDDCs. (<b>B</b>) Slit2/...
<p>(<b>A</b>) Robo4 immunoprecipitation of α<sub>5</sub>β<sub>1</sub> integrin by Western blot analy...
A hallmark of many pathogenic diseases is localized inflammation and influx of leukocytes. The neuro...
HIV-1 traffics through dendritic cells (DCs) en route to establishing a productive infection in T ly...
Dendritic cells (DC) are one of the earliest targets of HIV-1 infection acting as a ‘Trojan Horse', ...
<p>(<b>A</b>) Representative Western blot analysis of phosphorylated c-Src in L-LECs after preincuba...
DCs are critical to the early events of HIV-1 infection. They are the first cells that HIV-1 encount...
Dendritic cells (DCs) are essential antigen-presenting cells for the induction of immunity against p...
Macrophages are one of the three main human cell types infected by HIV-1. They are highly plastic ce...