Iqbal et al, Van Wyk-Grumbach syndrome

In boys precocious puberty is defined as the devel-opment of secondary sexual characters before 9 year of age. In girls, the development of breasts (thelarche) before 7.5 year, the development of pu-bic hairs (pubarche) before 8.5 year or menarche before the age of 9.5 year is considered precocious [1]. Hypothyroidism is usually associated with de-layed puberty and rarely with precocious puberty [2]. Hypothyroidism with precocious puberty was first described by Kendle in 1905 [3]. Van Wyck and Grumbach reported the association of multi-cystic ovaries with hypothyroidism and precocious puberty [4]. This pathology is more frequently seen in girls. Precocious puberty is always isosexual and charac-terized by breast enlargement, multicystic ovarie