Add to ORKGAbstract: The indolocarbazole (ICZ) alkaloids have attracted much attention due to their unique structures and potential therapeutic applications. A series of ICZs were recently isolated and identified from a marine-derived actinomycete strain, Streptomyces sanyensis FMA. To elucidate the biosynthetic machinery associated with ICZs production in S. sanyensis FMA, PCR using degenerate primers was carried out to clone the FAD-dependent monooxygenase gene fragment for ICZ ring formation, which was used as a probe to isolate the 34.6-kb DNA region containing the spc gene cluster. Sequence analysi
BACKGROUND: Carbazole is a recalcitrant compound with a dioxin-like structure and possesses mutageni...
Abstract: Polyporus umbellatus is one of the most widely used and precious medicinal fungi and the u...
AbstractRebeccamycin, a halogenated natural product of the indolocarbazole family, is produced by Sa...
Among the indolocarbazole alkaloids of antitumor antibiotics, K-252a represents a structurally uniqu...
Indolocarbazole (ICZ) alkaloid constitutes a group of natural products which manifested powerful bio...
The cladoniamides are bis-indole alkaloids isolated from Streptomyces uncialis, a lichen-associated ...
Indole, a derivative of the amino acid tryptophan, is a toxic signaling molecule, which can inhibit ...
A large and rapidly increasing number of unstudied “orphan ” natural product biosynthetic gene clust...
Background: Actinoplanes sp. SE50/110 is known as the wild type producer of the alpha-glucosidase in...
SummaryAT2433, an indolocarbazole antitumor antibiotic, is structurally distinguished by its aminodi...
Abstract: Ilex asprella, a plant widely used as a folk herbal drug in southern China, produces and s...
The rimJ gene, which codes for a crotonyl-CoA carboxylase/reductase, lies within the bio-synthetic g...
Streptomyces lomondensis S015 synthesizes the broad-spectrum phenazine antibiotic lomofungin. Whole ...
Background Streptomyces are well known for their capability to produce many bioactive secondary meta...
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
BACKGROUND: Carbazole is a recalcitrant compound with a dioxin-like structure and possesses mutageni...
Abstract: Polyporus umbellatus is one of the most widely used and precious medicinal fungi and the u...
AbstractRebeccamycin, a halogenated natural product of the indolocarbazole family, is produced by Sa...
Among the indolocarbazole alkaloids of antitumor antibiotics, K-252a represents a structurally uniqu...
Indolocarbazole (ICZ) alkaloid constitutes a group of natural products which manifested powerful bio...
The cladoniamides are bis-indole alkaloids isolated from Streptomyces uncialis, a lichen-associated ...
Indole, a derivative of the amino acid tryptophan, is a toxic signaling molecule, which can inhibit ...
A large and rapidly increasing number of unstudied “orphan ” natural product biosynthetic gene clust...
Background: Actinoplanes sp. SE50/110 is known as the wild type producer of the alpha-glucosidase in...
SummaryAT2433, an indolocarbazole antitumor antibiotic, is structurally distinguished by its aminodi...
Abstract: Ilex asprella, a plant widely used as a folk herbal drug in southern China, produces and s...
The rimJ gene, which codes for a crotonyl-CoA carboxylase/reductase, lies within the bio-synthetic g...
Streptomyces lomondensis S015 synthesizes the broad-spectrum phenazine antibiotic lomofungin. Whole ...
Background Streptomyces are well known for their capability to produce many bioactive secondary meta...
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
BACKGROUND: Carbazole is a recalcitrant compound with a dioxin-like structure and possesses mutageni...
Abstract: Polyporus umbellatus is one of the most widely used and precious medicinal fungi and the u...
AbstractRebeccamycin, a halogenated natural product of the indolocarbazole family, is produced by Sa...