Add to ORKGBackground Recently cardiomyocyte progenitor cells (CMPCs) were successfully isolated from fetal and adult human hearts. Direct intramyocardial injection of human CMPCs (hCMPCs) in experi-mental mouse models of acute myocardial infarction significantly improved cardiac function compared to controls. Aim Here, our aim was to investigate whether xenotransplantation via intracoronary infusion of fetal hCMPCs in a pig model of chronic myocardial infarction is safe and efficacious, in view of translation purposes. Methods & Results We performed a randomized, blinded, placebo controlled trial. Four weeks after ischemia/ reperfusion injury by 90 minutes of percutaneous left anterior descending artery occlusion, pigs (n = 16, 68.5 ± 5.4 kg) rec...
International audienceEvaluation of: Williams AR, Trachtenberg B, Velazquez DL et al. Intramyocardia...
Cardiotoxicity testing is a key activity in the pharmaceutical industry in order to detect detriment...
BackgroundDespite the prevalence of right ventricular (RV) failure in congenital heart diseases, cel...
BACKGROUND: Recently cardiomyocyte progenitor cells (CMPCs) were successfully isolated from fetal an...
Background: Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) were recently shown to be ca...
. These authors contributed equally to this work. Background: Epicardial injection of heart-derived ...
ObjectivesThis study was designed to determine whether controlled release of basic fibroblast growth...
Summary: Non-human primates (NHPs) can serve as a human-like model to study cell therapy using induc...
licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that th...
Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen that is angiogenic...
. These authors contributed equally to this work. As heart failure due to myocardial infarction rema...
BackgroundCell therapy using intramyocardial injections of cardiac progenitors issued from human emb...
<div><p>Induced pluripotent stem (iPS) cells have the potential to differentiate to various types of...
Background: Allogeneic cardiac-derived progenitor cells (CPC) without immunosuppression could provid...
Rationale: Induced pluripotent stem cells (iPSCs) hold great promise for the development of patient-...
International audienceEvaluation of: Williams AR, Trachtenberg B, Velazquez DL et al. Intramyocardia...
Cardiotoxicity testing is a key activity in the pharmaceutical industry in order to detect detriment...
BackgroundDespite the prevalence of right ventricular (RV) failure in congenital heart diseases, cel...
BACKGROUND: Recently cardiomyocyte progenitor cells (CMPCs) were successfully isolated from fetal an...
Background: Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) were recently shown to be ca...
. These authors contributed equally to this work. Background: Epicardial injection of heart-derived ...
ObjectivesThis study was designed to determine whether controlled release of basic fibroblast growth...
Summary: Non-human primates (NHPs) can serve as a human-like model to study cell therapy using induc...
licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that th...
Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen that is angiogenic...
. These authors contributed equally to this work. As heart failure due to myocardial infarction rema...
BackgroundCell therapy using intramyocardial injections of cardiac progenitors issued from human emb...
<div><p>Induced pluripotent stem (iPS) cells have the potential to differentiate to various types of...
Background: Allogeneic cardiac-derived progenitor cells (CPC) without immunosuppression could provid...
Rationale: Induced pluripotent stem cells (iPSCs) hold great promise for the development of patient-...
International audienceEvaluation of: Williams AR, Trachtenberg B, Velazquez DL et al. Intramyocardia...
Cardiotoxicity testing is a key activity in the pharmaceutical industry in order to detect detriment...
BackgroundDespite the prevalence of right ventricular (RV) failure in congenital heart diseases, cel...