Research Article Ergosterol Alleviates Kidney Injury in Streptozotocin-Induced Diabetic Mice

permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Ergosterol (ERG) has been widely used in the development of novel drugs due to its unique physiological function. However, little is known about the protective effects of ERG on diabetes. Hence, the current study was designed to evaluate the positive role of ergosterol on streptozotocin- (STZ-) induced diabetes in mice. Oral glucose tolerance test (OGTT) was carried out to assess blood glucose level. Biochemical parameters such as uric acid, creatinine, serum insulin, triglycerides (TG), and total cholesterol (TC) were alsomeasured. Pathological condition of kidney was examined by hematoxylin-eosin (H&E) staining.The expressions of PI3K, p-PI3K, Akt, p-Akt, NF