One-Hour Glucose During an Oral Glucose Challenge Prospectively Predicts b-Cell Deterioration and Prediabetes in Obese Hispanic Youth

OBJECTIVEdIn adults, 1-h glucose during an oral glucose tolerance test (OGTT) predicts the development of type 2 diabetes independent of fasting and 2-h glucose concentrations. The purpose of the current investigation was to examine the utility of elevated 1-h glucose levels to prospectively predict deterioration in b-cell function and the development of prediabetes in high-risk youth. RESEARCH DESIGN AND METHODSdObese Latino youth with a family history of type 2 diabetes (133 male and 100 female; age 11.16 1.7 years) completed a baseline OGTT and were divided into two groups based upon a 1-h glucose threshold of 155 mg/dL (,155 mg/dL, n = 151, or$155mg/dL, n = 82). Youthwere followed annually for up to 8 years for assessment of glucose tolerance, body composition by dual-energy X-ray absorptiometry, and insulin sensi-tivity, insulin secretion, and the disposition index by the frequently sampled intravenous glucose tolerance test. RESULTSdOver time, the $155 mg/dL group exhibited a significantly greater decline in b-cell function compared with youth with a 1-h glucose,155 mg/dL (b = 2327.8 6 126.2, P = 0.01). Moreover, this decline was independent of fasting or 2-h glucose and body compo