Association Between Insulin Resistance and Oxidative Stress Parameters in Obese Adolescents with Non-Alcoholic Fatty Liver Disease

In tro duc ti on The prevalence of obesity has increased dramatically in children and adolescents in both developed and developing countries and is becoming an important medical problem. In recent years, pediatric non-alcoholic fatty liver disease (NAFLD) has increased in line with the increased prevalence of pediatric obesity and has also become an important worldwide health problem (1,2). The estimated prevalence of pediatric NAFLD varies between 2.6 % and 9.6 % and is associated with sex, age, and ethnicity (3,4). Fatty liver, the earliest and most prevalent stage of NAFLD (5,6), is thought to sensitize the liver to additional necroinflammatory insults (7), thus promoting disease progression to steatohepatitis and cirrhosis. A number of factors point to the multifactorial nature of this disease