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Central European Journal of Immunology 2014; 39(2)152 Experimental immunology DOI: 10.5114/ceji.2014.43714

Ming Zhu
Qi Xu
Xue-liang Li
Qiang He
Xue-liang Li
Wei-feng Wang

Publication date

August 2016

Abstract

Modulating effects of leflunomide on the balance of Th17/Treg cells in collagen-induced arthritis DBA/1 mic

Extracted data

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<p><b>Copyright information:</b></p><p>Taken from "The active metabolite of leflunomide, A77 1726, i...

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December 2011

<p><b>Copyright information:</b></p><p>Taken from "The active metabolite of leflunomide, A77 1726, i...

Nimesulide improves the symptomatic and disease modifying effects of leflunomide in collagen induced arthritis

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Al-Abbasi, F
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El-Eraky, W
Nagy, A
Abdel-Naim, AB

January 2014

Nimesulide is a COX-2 inhibitor used for symptomatic relief of rheumatoid arthritis. Leflunomide is ...

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Al-Abd, AM
Al-Abbasi, FA
Nofal, SM
Khalifa, AE
Williams, RO
El-Eraky, WI
Nagy, AA
Abdel-Naim, AB

November 2014

Nimesulide is a COX-2 inhibitor used for symptomatic relief of rheumatoid arthritis. Leflunomide is ...

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Montagna, Paola
Soldano, Stefano
Brizzolara, Renata
Villaggio, Barbara
Triolo, Pf
Clerico, P
Felli, Lamberto
Meroni, M
Sulli, Alberto
Seriolo, Bruno
Secchi, Me
Cutolo, Maurizio

January 2009

Clinical and experimental evidence indicates that rheumatoid arthritis prevalence is greater in fema...

Dynamic effects of leflunomide on IL-1, IL-6, and TNF-alpha activity produced from peritoneal macrophages in adjuvant arthritis rats

Li, WD
Ran, GX
Teng, HL
Lin, ZB

January 2002

AIM: To investigate the effects of leflunomide (LEF) on modulating interleukin-1 (IL-1), interleukin...

Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells.

Notley, CA
Inglis, JJ
Alzabin, S
McCann, FE
McNamee, KE
Williams, RO

October 2008

IL-17 is implicated in the pathogenesis of rheumatoid arthritis (RA) and has previously been shown t...

L161982 alleviates collagen-induced arthritis in mice by increasing Treg cells and down-regulating Interleukin-17 and monocyte-chemoattractant protein-1 levels

Liang Chen
Xianglei Wu
Jun Zhong
Dongqing Li

November 2017

Abstract Background To investigate the effects and potential mechanism of L161982 (a kind of EP4 ant...

Leptin exacerbates collagen-induced arthritis via enhancement of Th17 cell response

Lu, L
Zhang, M
Wang, X
Ko, KH
Hua, Z
Sun, L
Cao, X
Deng, J
Liu, Y
Yang, M
Wang, S

January 2012

OBJECTIVE: To determine the role of leptin in modulating Th17 cell response and joint inflammation i...

The active metabolite of leflunomide, A77 1726, inhibits the production of prostaglandin E2, matrix metalloproteinase 1 and interleukin 6 in human fibroblast‐like synoviocytes

Burger, D.
Begué‐Pastor, N.
Benavent, S.
Gruaz, L.
Kaufmann, M.‐T
Chicheportiche, R.
Dayer, J.‐M

August 2017

Objectives. To investigate the effects of the active metabolite of leflunomide, A77 1726, on fibrobl...

Research Article Attenuation of Collagen-Induced Arthritis in Mice by

Salmon Proteoglycan
Sayuri Yoshimura
Krisana Asano
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August 2016

Copyright © 2014 Sayuri Yoshimura et al. This is an open access article distributed under the Creati...

Effect of indomethacin on IL-1 receptor antagonist (IL-1Ra) secretion in human synovial fibroblasts and articular chondrocytes

Gaby Palmer (636)
Danielle Burger (56217)
Francoise Mezin (638)
David Magne (18950)
Cem Gabay (642)
Jean-Michel Dayer (10915)
Pierre-Andre Guerne (637)

December 2011

<p><b>Copyright information:</b></p><p>Taken from "The active metabolite of leflunomide, A77 1726, i...

EFFECTS OF LEFLUNOMIDE AND ITS ACTIVE METABOLITE ON THE PRODUCTION AND mRNA EXPRESSION OF TNF-α IN PERITONEAL MACROPHAGES AND SYNOVIAL CELLS WITH ADJUVANT ARTHRITIS IN RATS

李卫东
林志彬

January 2002

目的观察免疫抑制剂来氟米特(leflunomide,LEF)及其活性代谢产物A771726(A77)对佐剂性关节炎(AA)模型大鼠TNF-α分泌活性及mRNA表达的影响.方法 TNF-α活性及mRNA...

The active metabolite of leflunomide, A77 1726, increases proliferation of human synovial fibroblasts in presence of IL-1β and TNF-α

Magne, D.
Mézin, F.
Palmer, G.
Guerne, P.

June 2018

Abstract.: Objective and design: Excessive synovial fibroblast (SF) proliferation is detrimental in ...