ORIGINAL CONTRIBUTIONS Weight Loss with Sleeve Gastrectomy in Obese Type 2 Diabetes Mellitus: Impact on Cardiac Function

# The Author(s) 2015. This article is published with open access at Springerlink.com Background Diabetic cardiomyopathy is an increasingly prevalent health issue, with no specific management options. We examined the impact of weight loss with sleeve gastrecto-my on diabetic cardiomyopathy. Methods Eight obese patients with type 2 diabetes undergoing sleeve gastrectomy had left ventricular (LV) systolic and dia-stolic function assessed by global longitudinal strain (GLS) and septal early diastolic velocity (e’) using echocardiography, before and 9 months after surgery. Results Following surgery, mean weight loss was 28.0±16 kg; body mass index (BMI) decreased from 44±9 to 35±6 kg/m2 (p<0.001). Glycaemic control improved with glycated haemoglobin (HbA1c) improving from 9.2 % at baseline to 6.7 % at follow-up (p=0.002), with a corresponding improve-ment in LV GLS from −13.2±3.7 to −19.7±2.2 % (p<0.001), and LV ejection fraction from 60±5 to 70±4 % (p<0.001). Improvement in GLSwas associated with the amount of weight lost (ρ=0.81, p=0.015). LV septal e ’ velocities increased, and LV filling pressures decreased after surgery. Conclusions Weight loss with sleeve gastrectomy in obese patients with type 2 diabetes is effective in improving glycaemic control in subjects with type 2 diabetes and results in significant improvement in both systolic and diastolic myo-cardial function