Review Article Role of Intracellular Ca2+ and Na+/Ca2+ Exchanger in the Pathogenesis of Contrast-Induced Acute Kidney Injury

  • Dingping Yang
  • Dingwei Yang
Publication date
August 2016

Abstract

Copyright © 2013 D. Yang and D. Yang.This is an open access article distributed under the Creative CommonsAttribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The precise mechanisms underlying contrast-induced acute kidney injury (CI-AKI) are not well understood. Intracellular Ca2+ overload is considered to be a key factor in CI-AKI. Voltage-dependent Ca2+ channel (VDC) and Na+/Ca2+ exchanger (NCX) system are the main pathways of intracellular Ca2+ overload in pathological conditions. Here, we review the potential underlying mechanisms involved in CI-AKI and discuss the role of NCX-mediated intracellular Ca2+ overload in the contrast media-induced re...

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