RESEARCH ARTICLE Non-genomic action of be

The exact interactions of the single inflammatory media-tors within the inflammatory cascade taking place during recurrent airway obstruction (RAO) in the horse are still unclear. Ex-vivo precision-cut lung slices (PCLS) from ter-minal airways of the horse offer a unique condition where the interaction of single inflammatory agents (i.e. bronch-oconstrictors) and anti-inflammatory agents (i.e. broncho-dilators) can be observed without multifactorial influence as occurs in vivo. This may be useful to further under-stand the pathogenesis of RAO. The aim of the study was to take a first step to analyse the interaction of two sub-stances involved in bronchoconstriction and bronchodila-tion in healthy pulmonary tissue of 13 horses. Synthetic glucocorticoids are recognized to be effective i