Background.High-gradegliomas (HGGs)account for15%ofall pediatricbrain tumorsandarea leadingcauseof cancer-relatedmortality andmorbidity. Pediatric HGGs (pHGGs) are histologically indistinguishable from their counterpart in adulthood. However, recent investi-gations indicate that differences occur at themolecular level, thus suggesting that themolecular path to gliomagenesis in childhood is distinct from that of adults. MicroRNAs (miRNAs) have been identified as key molecules in gene expression regulation, both in develop-ment and in cancer. miRNAs have been investigated in adult high-grade gliomas (aHGGs), but scant information is available for pHGGs. Methods.We explored the differences in microRNAs between pHGG and aHGG, in both fresh-froz...
Despite extensive experimentation on pediatric tumors of the central nervous system (CNS), related t...
Glioblastoma Multiforme (GB) is the most common malignant human glioma and is currently incurable. F...
Tumours in the central nervous system are accountable for the majority of cancer-related deaths in c...
Background. High-grade gliomas (HGGs) account for 15% of all pediatric brain tumors and are a Leadin...
Malignant astrocytoma includes anaplastic astrocytoma (grade III) and glioblastoma (grade IV). Among...
MicroRNAs are a novel class of gene regulators and are involved in several physiologic cellular mech...
A major challenge in cancer research field is to define molecular features that distinguish cancer s...
<div><p>A major challenge in cancer research field is to define molecular features that distinguish ...
The mechanisms by which microRNAs control pediatric high-grade gliomas (pHGGs) have yet to be fully ...
MicroRNAs (miRNAs/miRs) are a novel class of gene regulators that may be involved in tumor chemoresi...
The mechanisms by which microRNAs control pediatric high-grade gliomas (pHGGs) have yet to be fully ...
Gliomas such as oligodendrogliomas (ODG) and glioblastomas (GBM) are brain tumours with different cl...
Abstract Understanding pediatric brain tumor biology is essential to help on disease stratification,...
<div><p>Glioblastoma is the most aggressive brain tumor that may occur in adults. Regardless of the ...
The role of microRNAs (miRNAs) in glioma biology is increasingly recognized. To investigate the regu...
Despite extensive experimentation on pediatric tumors of the central nervous system (CNS), related t...
Glioblastoma Multiforme (GB) is the most common malignant human glioma and is currently incurable. F...
Tumours in the central nervous system are accountable for the majority of cancer-related deaths in c...
Background. High-grade gliomas (HGGs) account for 15% of all pediatric brain tumors and are a Leadin...
Malignant astrocytoma includes anaplastic astrocytoma (grade III) and glioblastoma (grade IV). Among...
MicroRNAs are a novel class of gene regulators and are involved in several physiologic cellular mech...
A major challenge in cancer research field is to define molecular features that distinguish cancer s...
<div><p>A major challenge in cancer research field is to define molecular features that distinguish ...
The mechanisms by which microRNAs control pediatric high-grade gliomas (pHGGs) have yet to be fully ...
MicroRNAs (miRNAs/miRs) are a novel class of gene regulators that may be involved in tumor chemoresi...
The mechanisms by which microRNAs control pediatric high-grade gliomas (pHGGs) have yet to be fully ...
Gliomas such as oligodendrogliomas (ODG) and glioblastomas (GBM) are brain tumours with different cl...
Abstract Understanding pediatric brain tumor biology is essential to help on disease stratification,...
<div><p>Glioblastoma is the most aggressive brain tumor that may occur in adults. Regardless of the ...
The role of microRNAs (miRNAs) in glioma biology is increasingly recognized. To investigate the regu...
Despite extensive experimentation on pediatric tumors of the central nervous system (CNS), related t...
Glioblastoma Multiforme (GB) is the most common malignant human glioma and is currently incurable. F...
Tumours in the central nervous system are accountable for the majority of cancer-related deaths in c...