Genetic Variation in KCNQ1 Associates With Fasting Glucose and -Cell Function A Study of 3,734 Subjects Comprising Three Ethnicities

subfamily, member 1 (KCNQ1) has been found through a ge-nome-wide association study to be a strong candidate for con-ferring susceptibility to type 2 diabetes in East Asian and European populations. Our objective was to describe the asso-ciation between polymorphisms at the KCNQ1 locus with insulin resistance, -cell function, and other type 2 diabetes–related traits in a sample of Chinese, Malays, and Asian Indians living in Singapore. RESEARCH DESIGN AND METHODS—We examined the associations between four previously reported KCNQ1 single-nucleotide polymorphisms (SNPs) with type 2 diabetes–related traits in 3,734 participants from the population-based 1998 Sin-gapore National Health Survey cohort (2,520 Chinese, 693 Malay, and 521 Asian Indians). Insulin resistance was calculated from fasting insulin and glucose using the homeostasis model assess