JCBNournal of Clinical Biochemistry and Nutrition0912-00091880 5 86the Society for Free Radical Rese rch JapanKyot, Japanjcbn13-370.3 64/jcb.13-37Original ArticleThe effects of soy isoflavone on bone density in north region of climacteric Chinese women

Copyright © 2013 JCBN2013This is an open access article distributed under the terms of theCreat ve Commons Attribution Licens, which permit unre-st icted use, distribution, and reproduction i any medium, p ovided the original work is prop rly cit d.Only a f w investiga i wer based on limb bone d nsity. This study evaluated the efficacy of soy isoflavone in the treatment of the principal menopausal disorders, limb bone density and the role of pathway. The research protocol involved the random sub division of the enrolled sample into two groups of 40 women, who were to receive treatment for 6 months with isoflavone (90 mg/day) and with placebo. All of the patients were asked to fill in a questionnaire concerning their complaints. BMD of the radius and tibia were measured using quantitative ultrasound. Bone metabolism indexes calcium, phosphorus and alkaline phosphatase (ALP) were examined regularly. Serum cytokines interleukin6 (IL6) and tumor necrosis factorα (TNFα) examined by ELISA. The results of the score of Kupperman table showed that the isoflavone can lead to a significant reduction in some of the disorders. Compared with placebo, the tibia bone density i