Extracellular glutamate is elevated following brain ischemia or trauma and contributes to neuronal injury. We tested the hypothesis that magnesium sulfate (MgSO4, 3 mM) protects against metabolic failure caused by excitotoxic glutamate exposure. Rat cortical neuron preparations treated in medium already containing a physiological concentration of Mg2+ (1 mM) could be segregated based on their response to glutamate (100 mM). Type I preparations responded with a decrease or small transient increase in oxygen consumption rate (OCR). Type II neurons responded with.50 % stimulation in OCR, indicating a robust response to increased energy demand without immediate toxicity. Pre-treatment with MgSO4 improved the initial bioenergetic response to glu...
Studies on the neuroprotective effect of magnesium treatment in animal models of focal and global ce...
Introduction: This review of literature is to demonstrate a role of group III metabotropic glutamate...
An acute injury to brain or spinal cord produces profound metabolic perturbation that extends and ex...
Extracellular glutamate is elevated following brain ischemia or trauma and contributes to neuronal i...
<p>Normalized <b>(A, B)</b> and absolute <b>(C, D)</b> O<sub>2</sub> consumption rates (OCRs) after ...
Magnesium sulphate (MgSO4) given to women in preterm labor reduces cerebral palsy in their offspring...
Excitotoxic disturbances during brain development were studied in the mouse using intracerebral inje...
Brain ischemia events are among the first three mortalities causes in the world associated with high...
[[abstract]]Glucose is the primary energy substrate for neurons. Glucose transporter 3 (Glut3) local...
Mg2+ is an important cation in our body. It is an essential cofactor for many enzymes. Despite many ...
<p>Neurons were pre-incubated for 1 hr in the absence or presence of MgSO<sub>4</sub> (3 or 10 mM). ...
Magnesium (Mg) is fundamental in the brain, where it regulates metabolism and neurotransmission and ...
Copyright © 2004 by the American College of Nutrition.Objective: Previous studies have demonstrated ...
Hypoxic insults initiate a cascade of biochemical events that result in irreversible neuronal damage...
Brain edema is a fatal complication of acute ischemic stroke and associated with worse outcomes in p...
Studies on the neuroprotective effect of magnesium treatment in animal models of focal and global ce...
Introduction: This review of literature is to demonstrate a role of group III metabotropic glutamate...
An acute injury to brain or spinal cord produces profound metabolic perturbation that extends and ex...
Extracellular glutamate is elevated following brain ischemia or trauma and contributes to neuronal i...
<p>Normalized <b>(A, B)</b> and absolute <b>(C, D)</b> O<sub>2</sub> consumption rates (OCRs) after ...
Magnesium sulphate (MgSO4) given to women in preterm labor reduces cerebral palsy in their offspring...
Excitotoxic disturbances during brain development were studied in the mouse using intracerebral inje...
Brain ischemia events are among the first three mortalities causes in the world associated with high...
[[abstract]]Glucose is the primary energy substrate for neurons. Glucose transporter 3 (Glut3) local...
Mg2+ is an important cation in our body. It is an essential cofactor for many enzymes. Despite many ...
<p>Neurons were pre-incubated for 1 hr in the absence or presence of MgSO<sub>4</sub> (3 or 10 mM). ...
Magnesium (Mg) is fundamental in the brain, where it regulates metabolism and neurotransmission and ...
Copyright © 2004 by the American College of Nutrition.Objective: Previous studies have demonstrated ...
Hypoxic insults initiate a cascade of biochemical events that result in irreversible neuronal damage...
Brain edema is a fatal complication of acute ischemic stroke and associated with worse outcomes in p...
Studies on the neuroprotective effect of magnesium treatment in animal models of focal and global ce...
Introduction: This review of literature is to demonstrate a role of group III metabotropic glutamate...
An acute injury to brain or spinal cord produces profound metabolic perturbation that extends and ex...