Rat strains differ dramatically in their susceptibility to mammary carcinogenesis. On the assumption that susceptibility genes are conserved across mammalian species and hence inform human carcinogenesis, numerous investigators have used genetic linkage studies in rats to identify genes responsible for differential susceptibility to carcinogenesis. Using a genetic backcross between the resistant Copenhagen (Cop) and susceptible Fischer 344 (F344) strains, we mapped a novel mammary carcinoma susceptibility (Mcs30) locus to the centromeric region on chromosome 12 (LOD score of,8.6 at th
<p>The genetic map positions of polymorphic STR markers are indicated by hatch marks and are designa...
Breast cancer risk is 31% heritable, yet the majority of the underlying risk factors remain poorly d...
Copenhagen rats are highly resistant to mammary carcinogenesis, even after treatment with chemical c...
Rat strains differ dramatically in their susceptibility to mammary carcinogenesis. On the assumption...
<div><p>Rat strains differ dramatically in their susceptibility to mammary carcinogenesis. On the as...
Women have inherited differences in their susceptibility to breast cancer, but the genes underlying ...
We previously mapped several quantitative trait loci (QTLs) controlling DMBA-induced mammary tumor d...
<p>A) Genetic map of the congenic lines contributing to the positional identification of the <i>Mcs1...
Breast cancer genetic susceptibility is modulated by high to low penetrance risk alleles. Population...
We previously mapped several quantitative trait loci (QTLs) con-trolling DMBA-induced mammary tumor ...
Although two major breast cancer susceptibility genes, BRCA1 and BRCA2, have been identified account...
Although two major breast cancer susceptibility genes, BRCA1 and BRCA2, have been identified account...
<p>Table legend: Genes and gene locations on rat chromosomes 1, 5, 9 and 18 regions as per RGD. nt, ...
Background: Epidemiological studies indicate that breast is one of the most susceptible organs to ra...
The COP and WKY rat strains are resistant to mammary cancer. It has shown previously that upon chemi...
<p>The genetic map positions of polymorphic STR markers are indicated by hatch marks and are designa...
Breast cancer risk is 31% heritable, yet the majority of the underlying risk factors remain poorly d...
Copenhagen rats are highly resistant to mammary carcinogenesis, even after treatment with chemical c...
Rat strains differ dramatically in their susceptibility to mammary carcinogenesis. On the assumption...
<div><p>Rat strains differ dramatically in their susceptibility to mammary carcinogenesis. On the as...
Women have inherited differences in their susceptibility to breast cancer, but the genes underlying ...
We previously mapped several quantitative trait loci (QTLs) controlling DMBA-induced mammary tumor d...
<p>A) Genetic map of the congenic lines contributing to the positional identification of the <i>Mcs1...
Breast cancer genetic susceptibility is modulated by high to low penetrance risk alleles. Population...
We previously mapped several quantitative trait loci (QTLs) con-trolling DMBA-induced mammary tumor ...
Although two major breast cancer susceptibility genes, BRCA1 and BRCA2, have been identified account...
Although two major breast cancer susceptibility genes, BRCA1 and BRCA2, have been identified account...
<p>Table legend: Genes and gene locations on rat chromosomes 1, 5, 9 and 18 regions as per RGD. nt, ...
Background: Epidemiological studies indicate that breast is one of the most susceptible organs to ra...
The COP and WKY rat strains are resistant to mammary cancer. It has shown previously that upon chemi...
<p>The genetic map positions of polymorphic STR markers are indicated by hatch marks and are designa...
Breast cancer risk is 31% heritable, yet the majority of the underlying risk factors remain poorly d...
Copenhagen rats are highly resistant to mammary carcinogenesis, even after treatment with chemical c...
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