An Appreciation of the Physician-Scientist The Macrophage in Cell Biology and Resistance to Infectious Disease A Complete Bibliography Summary

1993. Cohn is best known as the father of the current era of macrophage biology. Many of his scientific accomplishments are recounted here, beginning with seminal studies on the granules of phagocytes that were performed with his close colleague and former editor of thisJournaI, James Hirsch. Cohn and Hirsch identified the granules as lysosomes that discharged their contents of digestive nzymes into vacuoles containing phagocytosed microbes. These findings were part of the formative ra of cell biology and initiated the modern study of endocytosis and cell-mediated resistance to infection. Cohn further ex-plored the endocytic apparatus inpioneering studies of the mouse peritoneal macrophage in culture. He described vesicular inputs from the cell surface and Golgi apparatus and documented the thoroughness of substrate digestion within lysosomal vacuoles that would only permit the egress of monosaccharides and amino acids. These discoveries created a vigorous environment for graduate students, postdoctoral fellows, and junior and visiting faculty. Some of the major findings that emerged from Cohn's collaborations included the radioiodination of the plasma membrane for studies of composition and turnover; membrane r cycling during endocytosis; the origin of the mononuclear phagocyte syste