PRIMARY RESEARCH Association between unde a u

Africa, meanwhile, the incidence has increased substan-tially in Europe and the United States. Studies have shown tors CC, epa-ome ring Liu et al. Cancer Cell International (2015) 15:62 DOI 10.1186/s12935-015-0214-0filtration play essential roles [10]. HCC patients withRegion 530021, P. R. China Full list of author information is available at the end of the articlethe process of HCC development, gene expression, cell apoptosis, cell migration, vaso-invasion and capsule in-†Equal contributors 1Department of Pathology, First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi Zhuang Autonomousand the third most common cause of cancer mortality worldwide [1–3]. The incidence of HCC is higher in male compared to the female. Among all cases, over 80 % of HCC patients occur in East Asia and sub-Saharan over the world, among which, three quarters occurre East Asian countries [4, 5]. Multiple etiological fac contribute to the carcinogenesis and progression of H for instance, infection of hepatitis B virus (HBV) or h titis C virus (HCV) and long-term exposure to s chemical agents (alcohol or aflatoxin B1) [6–9]. Du * Correspondence