ASIC subunit ratio and differential surface trafficking in the brain Junjun Wu1,2, Yuanyuan Xu1,3, Yu-Qing Jiang1,4, Jiangping Xu3, Youjia Hu2 and Xiang-ming Zha1* Background: Acid-sensing ion channels (ASICs) are key mediators of acidosis-induced responses in neurons. However, little is known about the relative abundance of different ASIC subunits in the brain. Such data are fundamental for interpreting the relative contribution of ASIC1a homomers and 1a/2 heteromers to acid signaling, and essential for designing therapeutic interventions to target these channels. We used a simple biochemical approach and semi-quantitatively determined the molar ratio of ASIC1a and 2 subunits in mouse brain. Further, we investigated differential surface tr...
AbstractMany central neurons possess large acid-activated currents, yet their molecular identity is ...
Acid-sensing ion channels (ASICs) generate H(+) -gated Na(+) currents that contribute to neuronal fu...
Acid-sensing ion channels (ASICs) are proton gated cation channels, which are involvedin many neuron...
Acid-sensing ion channels (ASICs) have an important influence on human physiology and pathology. The...
Graduation date: 2008This study examined the role of acid- sensing ion channels (ASICs) in interneur...
Proton receptors of the acid-sensing ion channel (ASIC) family are expressed in sensory neurons and ...
Acid-sensing ion channels (ASICs) belong to the family of the epithelial sodium channel/degenerin (E...
Abstract Extracellular acidification occurs in the brain with elevated neural activity, increased me...
Acid-sensing ion channels (ASICs) are proton-gated cation channels and key mediators of responses to...
Acid-sensing ion channels (ASICs) are H+-gated Na+ channels, which are present in most, if not all, ...
Acid-sensing ion channel-1a (ASIC1a), the primary proton receptor in the brain, contributes to multi...
A significant drop of tissue pH or acidosis is a common feature of acute neurological conditions suc...
Neuroscience - Vision & Functional Brain Imaging Poster SessionImproving the treatment and preventio...
The chicken acid-sensing ion channel ASIC1 has been crystallized as a homotrimer. We address here th...
Acid-sensing ion channels (ASICs, nomenclature as agreed by NC-IUPHAR [35]) are members of a Na+ cha...
AbstractMany central neurons possess large acid-activated currents, yet their molecular identity is ...
Acid-sensing ion channels (ASICs) generate H(+) -gated Na(+) currents that contribute to neuronal fu...
Acid-sensing ion channels (ASICs) are proton gated cation channels, which are involvedin many neuron...
Acid-sensing ion channels (ASICs) have an important influence on human physiology and pathology. The...
Graduation date: 2008This study examined the role of acid- sensing ion channels (ASICs) in interneur...
Proton receptors of the acid-sensing ion channel (ASIC) family are expressed in sensory neurons and ...
Acid-sensing ion channels (ASICs) belong to the family of the epithelial sodium channel/degenerin (E...
Abstract Extracellular acidification occurs in the brain with elevated neural activity, increased me...
Acid-sensing ion channels (ASICs) are proton-gated cation channels and key mediators of responses to...
Acid-sensing ion channels (ASICs) are H+-gated Na+ channels, which are present in most, if not all, ...
Acid-sensing ion channel-1a (ASIC1a), the primary proton receptor in the brain, contributes to multi...
A significant drop of tissue pH or acidosis is a common feature of acute neurological conditions suc...
Neuroscience - Vision & Functional Brain Imaging Poster SessionImproving the treatment and preventio...
The chicken acid-sensing ion channel ASIC1 has been crystallized as a homotrimer. We address here th...
Acid-sensing ion channels (ASICs, nomenclature as agreed by NC-IUPHAR [35]) are members of a Na+ cha...
AbstractMany central neurons possess large acid-activated currents, yet their molecular identity is ...
Acid-sensing ion channels (ASICs) generate H(+) -gated Na(+) currents that contribute to neuronal fu...
Acid-sensing ion channels (ASICs) are proton gated cation channels, which are involvedin many neuron...