Background

Dengue is a viral systemic disease caused by an arboviral of Flaviviridae family, affecting about a 700 thousand cases per year in Brazil. It is endemic in tropical regions such as Southeast Asia, South Pacific, East Africa, Carib-bean and Latin America. The disease is transmitted by Aedes aegypti (Linnaeus, 1762), a mosquito that is the main target for the disease control through strategies ranging from the larval to the adult combat. The larvi-cides commonly used to combat the vector, besides being toxic, present drop in larvicide efficacy since the A. aegypti larvae has developed resistance to these pro-ducts. Thus, the search for new active principles that are effective in combating the mosquito is required. In this sense, Agave sisalana is a plant that is produced in several states in the Brazilian northeast region, which i