RESEARCH ARTICLE Rapid and Efficient Production of Coronary Artery Ligation and Myocardial Infarction in Mice Using Surgical Clips

Aims The coronary artery ligation model in rodents mimics human myocardial infarction (MI). Nor-mally mechanical ventilation and prolonged anesthesia period are needed. Recently, a method has been developed to create MI by popping-out the heart (without ventilation) fol-lowed by immediate suture ligation. Mortality is high due to the time-consuming suture liga-tion process while the heart is exposed. We sought to improve this method and reduce mortality by rapid coronary ligation using a surgical clip instead of a suture. Methods and Result