Agonist-bound structure of the human P2Y12 receptor. Nature 509, 119–122. doi: 10.1038/nature13288

The P2Y12 receptor (P2Y12R), one of eight members of the P2YR family expressed in humans, has been identified as one of the most prominent clinical drug targets for inhibition of platelet aggregation. Consequently, extensive mutagenesis and modeling studies of the P2Y12R have *To whom correspondence should be addressed