Experimental Crystal data

R factor = 0.044; wR factor = 0.081; data-to-parameter ratio = 20.8. The title molecule, C22H17F3N2OS, adopts a trans–cis confor-mation with respect to the positions of the carbonyl and trifluoromethylbenzene groups against the thiocarbonyl group across the C—N bonds. The molecular structure is stabilized by an intramolecular N—H O hydrogen bond with an S(6) ring motif. The trifluoromethyl-substituted benzene ring forms dihedral angles of 66.05 (9) and 47.19 (9) with the terminal phenyl rings and is twisted from the O C—N—(C S)—N carbonylthiourea plane [maximum deviation = 0.0535 (12) Å], making a dihedral angle of 63.59 (8). In the crystal, N— H O and C—H F hydrogen bonds link the molecules into a layer parallel to the bc plane. A C—H interaction is also observed. Related literature For the biological activity of thiourea derivatives, see: Vankatachalam et al. (2001). For related structures, see: Yusof, Arshad et al. (2012); Yusof, Embong et al. (2012); Yusof, Mutalib et al. (2012). For hydrogen-bond motifs, see: Bernstein et al. (1995). For bond-length data, see: Allen et al. (1987). For the stability of the temperature controller used for the dat