www.jnmjournal.org Achalasia- An Update

Achalasia is an esophageal motility disorder of unknown cause, characterized by aperistalsis of the esophageal body and im-paired lower esophageal sphincter relaxation. Patients present at all ages, primarily with dysphagia for solids/liquids and bland regurgitation. The diagnosis is suggested by barium esophagram and confirmed by esophageal manometry. Achalasia cannot be cured. Instead, our goal is to relieve symptoms, improve esophageal emptying and prevent the development of megaeso-phagus. The most successful therapies are pneumatic dilation and surgical myotomy. The overall success rate of graded pneu-matic dilation is 78%, with women and older patients responding best. Laparoscopic myotomy, usually combined with a parti-al fundoplication, has an overall success rate of 87%. Young patients, especially men, are the best candidates for surgical myotomy. Botulinum toxin injection into the lower esophageal sphincter and smooth muscle relaxants are usually reserved for older patients or those with co-morbid illness. The prognosis for achalasia patients to return to near normal swallowing is good, but the disease is rarely “cured ” with a single procedure and intermittent touch-up procedures may be required. (J Neurogastroenterol Motil 2010;16:232-242