All class I phosphoinositide 3-kinases (PI3Ks) associate tightly with regulatory subunits through interactions that have been thought to be constitutive. PI3Kc is key to the regulation of immune cell responses activated by G protein-coupled receptors (GPCRs). Remarkably we find that PKCb phosphorylates Ser582 in the helical domain of the PI3Kc catalytic subunit p110c in response to clustering of the high-affinity IgE receptor (FceRI) and/or store-operated Ca2+- influx in mast cells. Phosphorylation of p110c correlates with the release of the p84 PI3Kc adapter subunit from the p84-p110c complex. Ser582 phospho-mimicking mutants show increased p110c activity and a reduced binding to the p84 adapter subunit. As functional p84-p110c is key to G...
Stimulation of macrophages by various ligands results in the activation of both phosphoinositide 3-k...
IgA binding to FcαRI (CD89) is rapidly enhanced by cytokine induced inside-out signaling. Dephosphor...
Stimulation of macrophages by various ligands results in the activation of both phosphoinositide 3-k...
<div><p>All class I phosphoinositide 3-kinases (PI3Ks) associate tightly with regulatory subunits th...
All class I phosphoinositide 3-kinases (PI3Ks) associate tightly with regulatory subunits through in...
International audienceAll class I phosphoinositide 3-kinases (PI3Ks) associate tightly with regulato...
International audienceAll class I phosphoinositide 3-kinases (PI3Ks) associate tightly with regulato...
International audienceAll class I phosphoinositide 3-kinases (PI3Ks) associate tightly with regulato...
International audienceAll class I phosphoinositide 3-kinases (PI3Ks) associate tightly with regulato...
All class I phosphoinositide 3-kinases (PI3Ks) associate tightly with regulatory subunits through in...
<p>In a resting mast cell, the PI3Kγ complex is responsive to GPCR-mediated dissociation of trimeric...
<p>Coincident with migration and adhesion of mast cells, adaptor protein p84 relays the GPCR signal ...
SummaryA variety of genetic and inhibitor studies have shown that phosphoinositide 3-kinase γ (PI3Kγ...
Phosphatidylinositol 3-kinase (PI3K) generates membrane phospholipids that serve as second messenger...
<p>(A) Schematic representation of the PKCβ-p110γ interaction: full-length (fl) PKCβ is in a closed ...
Stimulation of macrophages by various ligands results in the activation of both phosphoinositide 3-k...
IgA binding to FcαRI (CD89) is rapidly enhanced by cytokine induced inside-out signaling. Dephosphor...
Stimulation of macrophages by various ligands results in the activation of both phosphoinositide 3-k...
<div><p>All class I phosphoinositide 3-kinases (PI3Ks) associate tightly with regulatory subunits th...
All class I phosphoinositide 3-kinases (PI3Ks) associate tightly with regulatory subunits through in...
International audienceAll class I phosphoinositide 3-kinases (PI3Ks) associate tightly with regulato...
International audienceAll class I phosphoinositide 3-kinases (PI3Ks) associate tightly with regulato...
International audienceAll class I phosphoinositide 3-kinases (PI3Ks) associate tightly with regulato...
International audienceAll class I phosphoinositide 3-kinases (PI3Ks) associate tightly with regulato...
All class I phosphoinositide 3-kinases (PI3Ks) associate tightly with regulatory subunits through in...
<p>In a resting mast cell, the PI3Kγ complex is responsive to GPCR-mediated dissociation of trimeric...
<p>Coincident with migration and adhesion of mast cells, adaptor protein p84 relays the GPCR signal ...
SummaryA variety of genetic and inhibitor studies have shown that phosphoinositide 3-kinase γ (PI3Kγ...
Phosphatidylinositol 3-kinase (PI3K) generates membrane phospholipids that serve as second messenger...
<p>(A) Schematic representation of the PKCβ-p110γ interaction: full-length (fl) PKCβ is in a closed ...
Stimulation of macrophages by various ligands results in the activation of both phosphoinositide 3-k...
IgA binding to FcαRI (CD89) is rapidly enhanced by cytokine induced inside-out signaling. Dephosphor...
Stimulation of macrophages by various ligands results in the activation of both phosphoinositide 3-k...