RESEARCH ARTICLE A Systematic Review of Pharmacological Treatment Options Used to Reduce Ischemia Reperfusion Injury in Rat Liver

Background Although animal studies models are frequently used for the purpose of attenuating ischemia reperfusion injury (IRI) in liver transplantation (LT), many of pharmacological agents have not become part of clinical routine. Methods A search was performed using the PubMed database to identify agents, fromwhich 58 arti-cles containing 2700 rat LT procedures were selected. The identified pharmacological agents were categorized as follows: I- adenosine agonists, nitric oxide agonists, endothelin antago-nists, and prostaglandins, II – Kupffer cell inactivator, III- complement inhibiter, IV- antioxi-dant, V- neutrophil inactivator, VI-anti-apoptosis agent, VII- heat shock protein and nuclear factor kappa B inducer, VIII- metabolic agent, IX- traditional Chinesemedicine, and X-others. Meta-analysis using 7-day-survival rate was also performed with Mantel-Haenszel's Random effects model. Result