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One of the goals in genetic research aims at identifying genes in biochemical and physiological processes to reveal genetic causes of rare and common diseases. Previous obstacles such as costly genotyp-ing or sequencing have been reduced with the chip-based genomewide association studies (GWAS), now culminating with the latest toy—next generation sequenc-ing methodologies (NGS). Concomitantly, computer technologies have evolved to an increasing use of multicore processors and distributed computing on large net-works or grids. Although the technologies are not perfect, we now have unprece