Invasion and Metastasis in the Viewpoint of Cell Adhesive Molecules

cell signaling pathways of transmembrane protein kinases such as receptor tyrosine kinase. However, they are also known to be in-volved in a wide range of other biological activities, including im-mune patrolling, cell migration, and binding of certain viruses to cells [3]. Invasion and metastasis are two distinguishing characteristics of cancer. These distort or disjoint the stable cell-cell and cell-matrix relation. Thus, the number of free or circulating integrins can be presumed to be larger during cancerous changes. As the author mentioned, these types of integrins might be correlated with circu-lating tumor cells away from the primary tumor site. In this point, we should consider integrins ’ roles again. Although they are an important structure of the cell membrane and are related to its sta-bility, as adhesive molecules, they might contrarily play certain roles in the process of tissue invasion and metastasis: for example