ORIGINAL RESEARCH ARTICLE Open Access Postoperative abnormal re r

Full list of author information is available at the end of the articleprimary reconstruction are common, and associated with functional morbidity and prolonged hospitalization [1]. Be-cause oral oncologic surgery is a clean-contaminated sur-gery, the postoperative surgical site infection (SSI) rate is high, occurring in approximately 20 % of patients [2,3]. Se-vere SSI in oral oncologic surgery sometimes causes oro-cervical fistula, which can be a heavy burden for patients and medical staff. Significant morbidity in the immediate postoperative period is also caused by non-wound infec-tions, with an incidence of 10 % in patients who undergo life-threatening for patients. Prediction for infectious com-plications contributes to their appropriate management. C-reactive protein (CRP) is an acute-phase reactant synthesized by hepatocytes, largely in response to pro-inflammatory cytokines [5]. CRP is not specific for a par-ticular disease because a rise in CRP level is observed with inflammation, trauma, malignancy, and tissue in-farction. CRP is present only in trace amounts in healthy subjects, and CRP levels increase within 6 hours after the onset of bacterial infection [6,7]. A rise in CRP levels may be earlier in a pathological process than other non-specific markers (e.g., fever), and falls rapidly on reso-lution of inflammation [8]. CRP is considered to b