RESEARCH ARTICLE Arctiin blocks hydrogen p h m

ive during normal metabolism and play pivotal roles in main-taining homeostasis [1]. Under stressful environmental con-disease and skin cancer [6]. Furthermore, accumulating evi-dence supports the hypothesis that oxidative stress caused Bae et al. Biological Research 2014, 47:50 http://www.biolres.com/content/47/1/50shown that the levels of apoptosis and senescence areNeungdong-ro, Gwangjin-gu, Seoul 143-701, Republic of Korea Full list of author information is available at the end of the articleditions (e.g., ionizing radiation, ultraviolet (UV) radiation, drugs, and smoke), the levels of ROS, including hydrogen peroxide (H2O2), are significantly increased [2]. These ROS subsequently activate various signaling molecules, including p53 and mitogen-activated protein kinase (MAPK) to in-duce cell growth arrest and apoptosis [3,4]. In skin, exogen-ous ROS can cause cellular damage, impaired collagen by H2O2 is a key factor in the onset and progression of hai