Editorial Mantle cell lymphoma: a model for risk-adapted treatment approach

Mantle cell lymphoma (MCL) is a rare but unique subtype of non-Hodgkin B-cell lymphoma that is molecularly characterized by the chromosomal translocation, t(11;14) (q13;q32) leading to the aberrant expression of cyclin D1, although a few cases are positive for cyclin D2 or D3 without expression of cyclin D1 [1, 2]. In the current issue of the Blood Research, Kang et al. reported the results of nationwide retrospective analysis regarding clinical features and treatment outcomes of 131 patients with MCL [3]. This is one of the largest series focused on MCL, especially in Asian patients. In the study, they summarized clinical features and treatment outcomes of MCL and validated the prognostic value of simplified MIPI (Mantle cell lymphoma International Prognostic Index) in Korean MCL patients. Although many studies about other subtypes of lymphoma