ABSTRACT: Carbonyl−carbonyl interactions between adjacent backbone amides have been implicated in the conformational stability of proteins. By combining experimental and computational approaches, we show that relevant amidic carbonyl groups associate through an n→π * donor−acceptor interaction with an energy of at least 0.27 kcal/mol. The n→π * interaction between two thioamides is 3-fold stronger than between two oxoamides due to increased overlap and reduced energy difference between the donor and acceptor orbitals. This result suggests that backbone thioamide incorporation could stabilize protein structures. Finally, we demonstrate that intimate carbonyl interactions are described more completely as donor−acceptor orbital interactions ra...
Protein structures are stabilized by multiple weak interactions, including the hydrophobic effect, h...
C–H/O interactions of aromatic C–H donors within proteins have been studied by analyzing the data in...
In this work, the influence of amide–π interactions on stability and properties of superoxide dismut...
Cataloged from PDF version of article.The overall contribution of backbone-backbone H-bonding to the...
Noncovalent interactions define and modulate biomolecular structure, function, and dynamics.1 A fund...
International audienceProtein structure and function is dependent on myriad noncovalent interactions...
International audienceProtein structure and function is dependent on myriad noncovalent interactions...
In this work, the influence of amide–π interactions on stability and properties of superoxide dismut...
Lone-pair···π and, more recently, π···π interactions have been studied in small molecule crystal str...
Protein structure and function is dependent on myriad noncovalent interactions. Direct detection and...
Noncovalent interactions are ubiquitous in biology, taking on roles that include stabilizing the con...
Abstract Screening of the Protein Data Bank led to identification of a recurring structural motif wh...
N-Methylacetamide, a model of the peptide unit in proteins, is allowed to interact with CH3SH, CH3SC...
Protein structures are stabilized by multiple weak interactions, including the hydrophobic effect, h...
Protein structures are stabilized by multiple weak interactions, including the hydrophobic effect, h...
Protein structures are stabilized by multiple weak interactions, including the hydrophobic effect, h...
C–H/O interactions of aromatic C–H donors within proteins have been studied by analyzing the data in...
In this work, the influence of amide–π interactions on stability and properties of superoxide dismut...
Cataloged from PDF version of article.The overall contribution of backbone-backbone H-bonding to the...
Noncovalent interactions define and modulate biomolecular structure, function, and dynamics.1 A fund...
International audienceProtein structure and function is dependent on myriad noncovalent interactions...
International audienceProtein structure and function is dependent on myriad noncovalent interactions...
In this work, the influence of amide–π interactions on stability and properties of superoxide dismut...
Lone-pair···π and, more recently, π···π interactions have been studied in small molecule crystal str...
Protein structure and function is dependent on myriad noncovalent interactions. Direct detection and...
Noncovalent interactions are ubiquitous in biology, taking on roles that include stabilizing the con...
Abstract Screening of the Protein Data Bank led to identification of a recurring structural motif wh...
N-Methylacetamide, a model of the peptide unit in proteins, is allowed to interact with CH3SH, CH3SC...
Protein structures are stabilized by multiple weak interactions, including the hydrophobic effect, h...
Protein structures are stabilized by multiple weak interactions, including the hydrophobic effect, h...
Protein structures are stabilized by multiple weak interactions, including the hydrophobic effect, h...
C–H/O interactions of aromatic C–H donors within proteins have been studied by analyzing the data in...
In this work, the influence of amide–π interactions on stability and properties of superoxide dismut...