CLINICAL REPORT e Gene for the

nucleotide in the 30 direction. cDNA analysis confirmed a p. chromosome 8q22.3 (NCBI 37/hg19) and contains 16 exons, which cysts, reduced or absent otoliths, malformed semicircular canals, insensitivities to sound stimulation, and abnormal swimming position despite the normal appearance of hair cells in the inner ear. Upon wild type human GRHL2 mRNA injection, the inner ear defects in the zebrafish were rescued, whereas injection with mutant human GRHL2 was unable to rescue otic defects [Han et al., 2011]. This suggests a conserved structure and function of GRHL2 in vertebrate inner ear development. s-Maximilians-4 Wuerzburg, Article first published online in Wiley Online Librar