Efficiency of Moxifloxacin in the Treatment of Helicobacter pylori Infection

To the Editor: We read the article of Chung et al.,1 “The efficacy of moxiflo-xacin-containing triple therapy after standard triple, sequen-tial, or concomitant therapy failure for Helicobacter pylori eradication in Korea ” with great interest. In this very well-designed study, the authors found that the eradication rate with moxifloxacin-containing triple therapy was lower than that of bismuth-containing quadruple therapy. These authors specu-lated that the failure of moxifloxacin-containing triple therapy in this study was primarily due to moxifloxacin resistance. These findings provide new information regarding moxifloxacin resistance to Helicobacter pylori. However, we believe that some points that should be emphasized in the study. First, in the first part of the methods section, the authors re-ported that the rapid urease test or histology was used for th