Despite profound importance in development and cancer, the extracellular cues that target cell invasions through basement membrane barriers remain poorly understood 1. A central obstacle has been the difficulty of studying the interactions between invading cells and basement membranes in vivo 2,3. Using the genetically and visually tractable model of C. elegans anchor cell (AC) invasion, we show that unc-6 (netrin) signaling, a pathway not previously implicated in controlling cell invasion in vivo, is a key regulator of this process. Site of action studies reveal that prior to invasion localized UNC-6 secretion directs its receptor, UNC-40, to the AC’s plasma membrane in contact with the basement membrane. There, UNC-40 polarizes a speciali...
Large gaps in basement membrane (BM) occur at sites of cell invasion and tissue remodelling in devel...
UNC-6/Netrin guides circumferential migrations along the dorso-ventral axis in C.elegans. Its recept...
Guiding neuronal growth cones to appropriate targets requires a combination of external cues that at...
<p>Basement membranes are dense, sheet-like forms of extracellular matrix that</p><p>surround the ep...
SummaryIntegrin expression and activity have been strongly correlated with developmental and patholo...
<p>Basement membrane (BM) is a dense, conserved sheet-like extracellular matrix that provides struct...
unc-6/netrin and its receptors, unc-5 and unc-40/d&barbelow;eleted in c&barbelow;olorectal c&barbelo...
<p>Basement membranes are a dense, sheet-like form of extracellular matrix that underlie epithelia a...
AbstractUNC-6 netrin, a laminin-related protein secreted from neuroglia and neurons along the ventra...
AbstractAn understanding of cell-invasive behavior has been limited by the lack of in vivo models wh...
SummaryCell invasion through basement membranes is crucial during morphogenesis and cancer metastasi...
<p>Basement membrane (BM) is the thin, dense, highly cross-linked form of extracellular matrix that ...
The receptor deleted in colorectal cancer (DCC) directs dynamic polarizing activities in animals tow...
How cells breach basement membrane barriers remains an area of active research. In this issue of Dev...
SummaryIn a tractable model for cell invasion, the Caenorhabditis elegans anchor cell migrates throu...
Large gaps in basement membrane (BM) occur at sites of cell invasion and tissue remodelling in devel...
UNC-6/Netrin guides circumferential migrations along the dorso-ventral axis in C.elegans. Its recept...
Guiding neuronal growth cones to appropriate targets requires a combination of external cues that at...
<p>Basement membranes are dense, sheet-like forms of extracellular matrix that</p><p>surround the ep...
SummaryIntegrin expression and activity have been strongly correlated with developmental and patholo...
<p>Basement membrane (BM) is a dense, conserved sheet-like extracellular matrix that provides struct...
unc-6/netrin and its receptors, unc-5 and unc-40/d&barbelow;eleted in c&barbelow;olorectal c&barbelo...
<p>Basement membranes are a dense, sheet-like form of extracellular matrix that underlie epithelia a...
AbstractUNC-6 netrin, a laminin-related protein secreted from neuroglia and neurons along the ventra...
AbstractAn understanding of cell-invasive behavior has been limited by the lack of in vivo models wh...
SummaryCell invasion through basement membranes is crucial during morphogenesis and cancer metastasi...
<p>Basement membrane (BM) is the thin, dense, highly cross-linked form of extracellular matrix that ...
The receptor deleted in colorectal cancer (DCC) directs dynamic polarizing activities in animals tow...
How cells breach basement membrane barriers remains an area of active research. In this issue of Dev...
SummaryIn a tractable model for cell invasion, the Caenorhabditis elegans anchor cell migrates throu...
Large gaps in basement membrane (BM) occur at sites of cell invasion and tissue remodelling in devel...
UNC-6/Netrin guides circumferential migrations along the dorso-ventral axis in C.elegans. Its recept...
Guiding neuronal growth cones to appropriate targets requires a combination of external cues that at...