Pseudoexfoliation Syndrome: The Puzzle Continues

Pseudoexfoliation (PXF) syndrome is a genetically determined, age-dependent generalized disorder of the elastic fiber system, characterized by excessive production and accumulation of an elastotic material within a multitude of intra- and extraocular tissues. Accumulation of this abnormal material in the aqueous humor outflow pathways predisposes to ocular hypertension and development of a severe type of open-angle glaucoma, known as PXF glaucoma, which represents the most common identifiable cause of open-angle glaucoma. Systemic manifestations of this abnormal matrix process appear to be associated with increased cardiovascular and cerebrovascular morbidity.