RESEARCH ARTICLE Targeting beta-Catenin sig

Full list of author information is available at the end of the articleBackground Despite significant advances toward targeted therapy and screening techniques, breast cancer continues to be the leading cause of cancer-related deaths and the most fre-quently diagnosed cancer among women in the USA and worldwide [1]. The clinical utility of ER antagonists is often limited by side effects [1]. Thus, the identifica-tion of novel agents that can suppress growth of both ER-positive and ER-negative human breast cancers and are still relatively safe is highly desirable. Gugulipid (GL, guggul, guggal, or gugul lipid) is the ethyl acetate extract of the gum guggul resin (raw mater-ial) harvested directly from the Commiphora mukul tre