ORIGINAL RESEARCH ARTICLE Impact of Specific KRAS Mutation in Exon 2 on Clinical Outcome of Chemotherapy- and Radiotherapy-Treated Colorectal Adenocarcinoma Patients

The Author(s) 2014. This article is published with open access at Springerlink.com Background and Objectives Knowledge obtained via high-throughput technologies, used for tumor genome sequencing or identifying gene expression and methylation signatures, is clinically applicable thanks to molecular characterization in the context of tumor development and progression. This study was conducted to assess the impact of specific KRAS mutation in codons 12 and 13 on clinical outcome of chemotherapy and radiotherapy in colorectal cancer patients. Methods A total of 239 samples of colorectal adenocar-cinoma underwent histological evaluation and DNA isolation. Results and Conclusions Patients with a mutation i