Add to ORKGMolecular profiling of tumor tissue to detect alterations, such as oncogenic mutations, plays a vital role in determining treatment options in oncology. Hence, there is an increasing need for a robust and high-throughput technology to detect oncogenic hotspot mutations. Although commercial assays are available to detect genetic alterations in single genes, only a limited amount of tissue is often available from patients, requiring multiplexing to allow for simultaneous detection of mutations in many genes using low DNA input. Even though next-generation sequencing (NGS) platforms provide powerful tools for this purpose, they face challenges such as high cost, large DNA input requirement, complex data analysis, and long turnaround times, lim...
Circulating tumour DNA (ctDNA) detection and monitoring have enormous potential clinical utility in ...
The current algorithm for Lynch syndrome diagnosis is highly complex with multiple steps which can r...
The inevitable switch from standard molecular methods to next-generation sequencing for the molecula...
Molecular profiling of tumor tissue to detect alterations, such as oncogenic mutations, plays a vita...
Molecular profiling of tumor tissue to detect alterations, such as oncogenic mutations, plays a vita...
Targeted anticancer therapies rely on the identification of patient subgroups most likely to respond...
<div><p>Targeted anticancer therapies rely on the identification of patient subgroups most likely to...
Detection of clinically actionable mutations in diagnostic tumour specimens aids in the selection of...
Stratification of patients for targeted and immune-based therapies requires extensive genomic profil...
Background: Sensitive and reliable molecular diagnostics is needed to guide therapeutic decisions fo...
The molecular characterization of tumors using next generation sequencing (NGS) is an emerging diagn...
Copyright © 2015 George J. Burghel et al. This is an open access article distributed under the Creat...
Detection of molecular tumor heterogeneity has become of paramount importance with the advent of tar...
We present a new next-generation sequencing-based method to identify somatic mutations of lung cance...
Somatic mutations play a major role in tumour initiation and progression. The mutation status of a t...
Circulating tumour DNA (ctDNA) detection and monitoring have enormous potential clinical utility in ...
The current algorithm for Lynch syndrome diagnosis is highly complex with multiple steps which can r...
The inevitable switch from standard molecular methods to next-generation sequencing for the molecula...
Molecular profiling of tumor tissue to detect alterations, such as oncogenic mutations, plays a vita...
Molecular profiling of tumor tissue to detect alterations, such as oncogenic mutations, plays a vita...
Targeted anticancer therapies rely on the identification of patient subgroups most likely to respond...
<div><p>Targeted anticancer therapies rely on the identification of patient subgroups most likely to...
Detection of clinically actionable mutations in diagnostic tumour specimens aids in the selection of...
Stratification of patients for targeted and immune-based therapies requires extensive genomic profil...
Background: Sensitive and reliable molecular diagnostics is needed to guide therapeutic decisions fo...
The molecular characterization of tumors using next generation sequencing (NGS) is an emerging diagn...
Copyright © 2015 George J. Burghel et al. This is an open access article distributed under the Creat...
Detection of molecular tumor heterogeneity has become of paramount importance with the advent of tar...
We present a new next-generation sequencing-based method to identify somatic mutations of lung cance...
Somatic mutations play a major role in tumour initiation and progression. The mutation status of a t...
Circulating tumour DNA (ctDNA) detection and monitoring have enormous potential clinical utility in ...
The current algorithm for Lynch syndrome diagnosis is highly complex with multiple steps which can r...
The inevitable switch from standard molecular methods to next-generation sequencing for the molecula...