Add to ORKGSystemic iron homeostasis involves a negative feedback circuit in which the expression level of the peptide hormone hepcidin depends on and controls the iron blood levels. Hepcidin expression is regulated by the BMP6/SMAD and IL6/STAT signaling cascades. Deregulation of either pathway causes iron-related diseases such as hemochromatosis or anemia of inflammation. We quantitatively analyzed how BMP6 and IL6 control hepcidin expression. Transcription factor (TF) phosphorylation and reporter gene expression were measured under co-stimulation conditions, and the promoter was perturbed by mutagenesis. Using mathematical modeling, we systematically analyzed potential mechanisms of cooperative and competitive promoter regulation by the transcripti...
AbstractThe inhibitory Smad7 acts as a critical suppressor of hepcidin, the major regulator of syste...
Iron, an essential nutrient, is required for many diverse biological processes. The absence of a def...
Iron, an essential nutrient, is required for many diverse biological processes. The absence of a def...
The inflammatory cytokine IL-6 directly regulates hepcidin through induction and subsequent promoter...
<p>(<b>A</b>) The presence of two BREs enhances promoter sensitivity towards BMP stimulation. Hepcid...
Hepcidin, a peptide hormone produced by hepatocytes, is the central regulator of systemic iron homeo...
The amount of iron in the plasma is determined by the regulated release of iron from most body cells...
Since its discovery in 2001, there have been a number of important discoveries and findings that hav...
Since its discovery in 2001, there have been a number of important discoveries and findings that hav...
Iron is vital for bodily function but is potentially toxic and accordingly, tightly controlled in th...
Iron is vital for bodily function but is potentially toxic and accordingly, tightly controlled in th...
Hepcidin is a peptide hormone that targets the iron exporter ferroportin, thereby limiting iron entr...
This chapter focuses on the signaling pathways involved in the synthesis of hepcidin, the iron hormo...
Iron is a metal element with crucial roles in human organism. Both iron deficiency and iron overload...
Iron is a metal element with crucial roles in human organism. Both iron deficiency and iron overload...
AbstractThe inhibitory Smad7 acts as a critical suppressor of hepcidin, the major regulator of syste...
Iron, an essential nutrient, is required for many diverse biological processes. The absence of a def...
Iron, an essential nutrient, is required for many diverse biological processes. The absence of a def...
The inflammatory cytokine IL-6 directly regulates hepcidin through induction and subsequent promoter...
<p>(<b>A</b>) The presence of two BREs enhances promoter sensitivity towards BMP stimulation. Hepcid...
Hepcidin, a peptide hormone produced by hepatocytes, is the central regulator of systemic iron homeo...
The amount of iron in the plasma is determined by the regulated release of iron from most body cells...
Since its discovery in 2001, there have been a number of important discoveries and findings that hav...
Since its discovery in 2001, there have been a number of important discoveries and findings that hav...
Iron is vital for bodily function but is potentially toxic and accordingly, tightly controlled in th...
Iron is vital for bodily function but is potentially toxic and accordingly, tightly controlled in th...
Hepcidin is a peptide hormone that targets the iron exporter ferroportin, thereby limiting iron entr...
This chapter focuses on the signaling pathways involved in the synthesis of hepcidin, the iron hormo...
Iron is a metal element with crucial roles in human organism. Both iron deficiency and iron overload...
Iron is a metal element with crucial roles in human organism. Both iron deficiency and iron overload...
AbstractThe inhibitory Smad7 acts as a critical suppressor of hepcidin, the major regulator of syste...
Iron, an essential nutrient, is required for many diverse biological processes. The absence of a def...
Iron, an essential nutrient, is required for many diverse biological processes. The absence of a def...