CeLL CyCLe news & views

The main feature of tumor cells is their abil-ity to divide unrestrictedly. Cellular division critically depends on successful mitosis. Thus, perhaps unsurprisingly, among the most pow-erful anticancer drugs are the ones that target mitosis. Proper segregation of chromosomes during mitosis is ensured by a highly coordi-nated and dynamic process of polymerization/ depolymerization of mitotic spindle microtu-bules. Hence, natural microtubule-poisoning drugs, such as Paclitaxel (PTX or Taxol) and vin-blastine are commonly used as anti-neoplas-tic agents for the treatment of solid tumors, including breast, ovarian, lung, and head and neck malignancies.1 The consequence o