Funding Information This work was supported in part by the

aThese authors contributed equally. Pancreatic neuroendocrine tumors (pNETs) are the second most common pan-creatic neoplasms, exhibiting a complex spectrum of clinical behaviors. To exam-ine the clinico-pathological characteristics associated with long-term prognosis we reviewed 119 patients with pNETs treated in a tertiary referral center using the WHO 2010 grading and the American Joint Committee on Cancer/Interna-tional Union Against Cancer (AJCC/UICC) staging systems, with a median fol-low-up of 38 months. Tumor size, immunohistochemistry (IHC) profiling and patient characteristics-determining stage were analyzed. Primary clinical out-comes were disease progression or death. The mean age at presentation was 52 years; 55 % were female patients, 11 % were associated with MEN1 (multiple endocrine neoplasia 1) or VHL (Von Hippel–Lindau); mean tumor diameter was 3.3 cm (standard deviation, SD) (2.92). The clinical presentation was incidental in 39 % with endocrine hypersecretion syndromes in only 24 % of cases. Never