OPEN LETTER TO THE EDITOR Identification of GSX2 and AF10 as NUP98 partner genes in

The Nucleoporin 98 gene (NUP98) is a promiscuous gene implicated in chromosomal aberrations in hematopoietic disorders. NUP98 encodes a 98-kDa protein of the nuclear pore complex that regulates nucleocytoplasmic transport of protein and RNA. Twenty-eight different NUP98 partner genes have been identified across various human hematological malignancies,1,2 many of which encode for homeodomain (HD) transcription factors and chromatin-modifying factors. We report here two new oncogenic fusions for NUP98, involving the homeobox gene genetic screened homeobox 2 (GSX2, formerly Gsh2) and the putative zinc-finger transcription factor gene ALL-1 fused gene from chromosome 10 (AF10)/MLLT10. Patient 1 is a 57-year-old woman with a post-myeloproliferative neoplasm M4 acute myeloid leukemia (AML) associated with a t(4;11)(q12;p15) translocation and trisomy 8. Patient 2 is a