ORIGINAL RESEARCH ARTICLE Comparison of Two Forms of Loperamide–Simeticone and a Probiotic Yeast (Saccharomyces boulardii) in the Treatment of Acute Diarrhoea in Adults: A Randomised Non-Inferiority Clinical

The Author(s) 2015. This article is published with open access at Springerlink.com Background Acute diarrhoea is a frequent health problem in both travellers and residents that has a social and eco-nomic impact. This study compared the efficacy and tol-erability of two loperamide–simeticone formulations and a Saccharomyces boulardii capsule as symptomatic treatment. Methods This was a prospective, randomised, single (investigator)-blind, three-arm, parallel group, non-inferi-ority clinical trial in adult subjects with acute diarrhoea at clinics in Mexico and India, with allocation to a lop-eramide–simeticone 2/125 mg caplet or chewable tablet (maximum eight in 48 h) or S. boulardii (250 mg twice daily for 5 days)